(586) Does Oxidative Stress Influence Erectile Dysfunction? Findings From Community and Dialysis Cohorts

Introduction The preceding evidences suggest that oxidative stress is closely associated with well-known risk factors of ED, including hypertension (HTN), dyslipidemia, diabetes mellitus (DM), metabolic syndrome, and hypogonadism. Therefore, numerous studies have investigated the role of oxidative stress in the etiology of ED using animal models and identified oxidative stress as a potential therapeutic target. However, the association between oxidative stress and ED in humans remains to be elucidated. Moreover, although it has been reported that end-stage renal disease (ESRD) and dialysis were associated with elevated oxidative stress, no study has investigated the association between oxidative stress and ED in patients with these backgrounds. Objective The aim of the present study was to investigate the association between oxidative stress and ED in community-dwelling men and men on dialysis. Methods This cross-sectional study included 398 community-dwelling men and 42 men on dialysis. Oxidative stress was assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG). Univariable and multivariable logistic regression analyses were performed to evaluate the association between oxidative stress and ED. Results Spearman’s rank correlation test showed no significant correlation between urine 8-OHdG levels and the 5-Item International Index of Erectile Function scores in community-dwelling men (ρ = −0.005, P = 0.917) and between plasma 8-OHdG levels and the Sexual Health Inventory for Men scores in men on dialysis (ρ = 0.166, P = 0.295). In community-dwelling men, univariable and multivariable analyses revealed that urine 8-OHdG level was not significantly associated with ED (odds ratio [OR]: 1.005, 95% confidence interval [CI]: 0.884–1.144, P = 0.934; OR: 0.930, 95% CI: 0.798–1.084, P = 0.353; respectively). In men on dialysis, univariable analyses revealed that plasma 8-OHdG level was not significantly associated with severe ED (OR: 0.967, 95% CI: 0.876–1.066, P = 0.498). Conclusions These results suggest that oxidative stress may not have an important contribution to the development and severity of ED in humans. Disclosure No