(587) Inflammation and Nutrition in Relation to Erectile Function Among Men Undergoing Dialysis

Introduction Low-grade systemic inflammation and malnutrition are frequently observed in chronic kidney disease patients. These conditions have been reported to contribute to the development of endothelial dysfunction, a well-known risk factor of ED. Moreover, several studies have reported the possible effects of low-grade systemic inflammation and malnutrition on the development of ED in men with chronic liver disease and healthy men. However, the role of these conditions in ED severity in men on dialysis remains to be elucidated. Objective We aimed to investigate the relationships of low-grade systemic inflammation and nutritional status with the severity of ED in men on hemodialysis (HD) and/or peritoneal dialysis (PD). Methods The present study included 71 men on dialysis. The Sexual Health Inventory for Men (SHIM) was used to assess ED. Men were classified as the mild/moderate (SHIM score ≥ 8) and severe ED (SHIM score ≤ 7) groups. C-reactive protein/albumin ratio (CAR) and Geriatric Nutritional Risk Index (GNRI) were used to evaluate low-grade systemic inflammation and nutritional status, respectively. We performed multivariate analysis to assess the relationships of CAR and GNRI with severe ED. Results The median age of the included men was 64 years old. All men had any degree of ED with 65% having severe ED. In the univariate analyses, a significant association was observed between elevated CAR (≥ 0.09) and severe ED (odds ratio [OR]: 4.038, P = 0.025), whereas no significant association was observed between lower GNRI (< 92) and severe ED (OR: 2.357, P = 0.109). In the multivariate analysis, an association between elevated CAR and severe ED was still significant (OR: 5.985, P = 0.010). Conclusions Low-grade systemic inflammation was significantly associated with ED severity, whereas lower GNRI was not. These results may be helpful for further research to identify the optimal treatment for men suffering from severe ED. Disclosure No