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June 6, 2026Open Access

Green and Efficient BPA-Catalyzed Synthesis of 1,4- Dihydropyridine-3,5-Dicarboxylates via One-Pot Hantzsch Reaction

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Authors

ATArchana ThubeG.S. Science, Arts And Commerce College

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Implication

Randomized trial demonstrates green synthesis of dihydropyridine derivatives, indicating a sustainable method.

Key Points

  • This study aims to develop a green and efficient method for synthesizing dihydropyridine derivatives using a biodegradable catalyst.
  • BPA-catalyzed one-pot Hantzsch multi-component reaction involving aldehydes, beta-keto esters, and ammonium acetate.
  • Reaction conducted in a water–ethanol solvent under reflux conditions.
  • Characterization of products done using FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry.
  • The reaction produced 1,4-dihydropyridine-3,5-dicarboxylates in excellent yields.
  • Significantly high atom economy with short reaction times.
  • Catalyst can be recycled multiple times without substantial loss of activity.

Cite This Study

Archana Thube (2026) studied this question.

synapsesocial.com/papers/6a23ba1771a5da9775e75c9chttps://doi.org/10.5281/zenodo.19331869
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Also Consider

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  1. 1Green and Efficient Synthesis of Dihydropyrimidinone Analogues via Hpa-Clay Catalyzed Biginelli Reaction2024
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  4. 4Eco-Friendly Microwave-Assisted Synthesis of Fused Pyrimido[4,5-d] Pyrimidine Derivatives via a Catalyst-Free Hantzsch Multicomponent Reaction2025 · 1 citations
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