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June 6, 2026Clinical Kidney JournalOpen Access

Male sex is linked to ~44% higher hypertension prevalence at ages 45-54, converging after 55.

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Why the study?

Sex differences in hypertension epidemiology and management are recognized, but how they vary across the adult life course remains incompletely understood.

Are there sex-specific differences in hypertension prevalence, awareness, treatment, and blood pressure control across the adult life course?

Population

10 000 participants from the Hamburg City Health Study in Germany

Comparison

Men vs women across age strata (45–54, 55–64, and 65–74 years)

Design

Cross-sectional analysis

Key result

Male sex was associated with higher hypertension prevalence than female sex (71% vs. 57%), particularly at ages 45-54 (PR 1.44, 95% CI 1.27-1.62), with convergence after age 55.

Authors

CTChristina ThompsonAKAlexandre KloppLDLeonie Dreher

Discussion

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Overview

Supports age-stratified hypertension screening in men; leaves open causal mechanisms and intervention effects.

Key Points

  • This analysis aims to investigate sex-specific differences in the prevalence, awareness, treatment, and control of hypertension across adulthood.
  • Cross-sectional analysis of 10,000 participants from the Hamburg City Health Study
  • Age-stratified comparisons (45–54, 55–64, 65–74 years)
  • Modified Poisson regression was used to assess differences adjusted for sociodemographic, comorbidity, and lifestyle factors.
  • Hypertension prevalence was higher in men (71%) compared to women (57%), especially at ages 45–54 (50% vs. 32%; adjusted PR 1.44, 95% CI 1.27–1.62)
  • Sex differences in prevalence decreased with age, converging at ages 65–74 (PR 1.04, 95% CI 0.99–1.08)
  • Awareness and treatment rates were similar between sexes, but blood pressure control remained low (∼40%) and declined in women at ages 65–74.

Study Design

Type

Cross-Sectional (n=10,000)

Structured PICO

Are there sex-specific differences in hypertension prevalence, awareness, treatment, and blood pressure control across the adult life course?

P
Population
10,000 adults (mean age 62 years, 51% women) from the Hamburg City Health Study assessed for sex differences in hypertension prevalence and management.
C
Comparator
Men versus women across age strata (45–54, 55–64, and 65–74 years)
O
Outcome
Sex-specific differences in hypertension prevalence, awareness, treatment, and blood pressure (BP) controlsurrogate

Main Result

Absolute Event Rate: 71% vs 57%

Hypertension prevalence is higher in men at younger ages but converges with women after age 55, highlighting the need for sex-specific, life stage-oriented screening and management.

Cite This Study

Thompson et al. (2026) conducted a cross-sectional in Hypertension (n=10,000). Male sex vs. Female sex was evaluated on Hypertension prevalence. Male sex was associated with higher hypertension prevalence than female sex (71% vs. 57%), particularly at ages 45-54 (PR 1.44, 95% CI 1.27-1.62), with convergence after age 55.

synapsesocial.com/papers/6a23ba1771a5da9775e75e65https://doi.org/10.1093/ckj/sfag180
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SEX DIFFERENCES IN HYPERTENSION PREVALENCE, TREATMENT AND CONTROL IN OLDER PEOPLE IN GERMANY: RESULTS OF THE NATINAL EXAMINATION SURVEY GESUNDHEIT 65+2024 · 1 citations
  2. 2Age and sex disparities in hypertension control: The multi-ethnic study of atherosclerosis (MESA)2021 · 57 citations
  3. 3SEX DIFFERENCES AND TREATMENT GAPS IN UNCONTROLLED HYPERTENSION: REAL-WORLD EVIDENCE FROM GERMANY2026
  4. 4Blood Pressure and Hypertension Among Adults Aged 80 and Above: Findings From the Population‐Based German Health Survey Gesundheit 65+2026
  5. 5Sex differences in blood pressure phenotypes over time – the HELIUS study2024 · 3 citations