June 1, 1983American Journal of Epidemiology
Determinants of Change in Blood Pressure During Childhood
Key result
Initial blood pressure levels were negatively associated with subsequent changes in systolic and diastolic pressure, suggesting no 'horse-racing' of blood pressure during childhood.
Population
462 Dutch children, aged 5-19 years, randomly selected from a general population in Zoetermeer, the…
Design
Cohort
Follow-up
3 to 7 annual measurements between 1975 and 1982
Authors
Discussion
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Implication
Does not support horse-racing BP changes in childhood; leaves open mechanisms in prospective cohorts.
Key Points
- The research aims to identify factors influencing changes in blood pressure among children aged 5-19 years.
- Analyzed blood pressure measurements from 462 Dutch children aged 5-19 years over several years (1975-1982)
- Utilized least-squares regression to assess blood pressure change over time for each participant
- Considered factors such as initial blood pressure, parental blood pressure, body weight, and serum uric acid levels in the analysis.
- Found that higher initial blood pressure levels negatively correlated with subsequent changes in systolic and diastolic pressure
- Initial serum uric acid levels positively influenced blood pressure changes in girls only
- No significant relationship between vascular reactivity and blood pressure change was observed.
Study Design
Type
Cohort (n=462)
Multicenter
No
Structured PICO
P
Population
462 children aged 5-19 years from a general Dutch population, followed with three to seven annual blood pressure measurements between 1975 and 1982.
O
Outcome
Rate of change in blood pressuresurrogate
Initial blood pressure levels in children are negatively associated with subsequent changes in blood pressure, suggesting no 'horse-racing' effect during childhood.
Cite This Study
Hofman et al. (1983) conducted a cohort in General population (n=462). Initial blood pressure and other baseline characteristics was evaluated on Rate of change in blood pressure. Initial blood pressure levels were negatively associated with subsequent changes in systolic and diastolic pressure, suggesting no 'horse-racing' of blood pressure during childhood.