HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

Xiaochen Ji; Huawen Huang; Yixi Zhang

doi:10.1039/d6ob00743k

January 1, 2026Organic & Biomolecular Chemistry

HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

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Key Points

The aim is to develop an efficient catalytic method for cross-dehydrogenative coupling (CDC) using HBr.
Utilized HBr as a catalyst for CDC reactions under aerobic conditions.
Investigated the coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes.
Analyzed reaction yields and atom economy.
Achieved high yields in CDC reactions without the need for transition metals.
Demonstrated a significant increase in atom economy compared to traditional methods.
Proved the effectiveness of HBr as a dual-functional catalyst.

Implication

Demonstrates efficient CDC reactions in quinoxalin-2(1H)-ones, suggesting a new catalytic approach.

Abstract

Cross-dehydrogenative coupling (CDC) reactions offer high atom economy and simple synthetic routes, and are widely employed for the coupling of heterocyclic rings. Herein, we report a transition-metal-free HBr-catalyzed aerobic CDC...

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Cite This Study

Ji et al. (2026) studied this question.

synapsesocial.com/papers/6a23ba6871a5da9775e761cb https://doi.org/10.1039/d6ob00743k

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HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

Key Points

Implication

Abstract

Discussion

Cite This Study

HBr as a dual functional catalyst enabling aerobic CDC coupling of quinoxalin-2(1H)-ones with electron-rich heteroarenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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