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The aim is to investigate magnetoencephalographic microstates in schizophrenia while controlling for treatment effects.

Magnetoencephalographic Microstates Reveal Disrupted Brain Activity Patterns in Schizophrenia Controlling for Treatment-Related Modulations

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The aim is to investigate magnetoencephalographic microstates in schizophrenia while controlling for treatment effects.
Studied magnetoencephalographic microstates in patients with schizophrenia, bipolar disorder, major depressive disorder, and controls.
Assessed treatment-related modulation effects and excluded treatment impacts to analyze differences between disorders.
Explored connections of altered microstates to cognitive dysfunction and sensory processing in schizophrenia.
Patients with schizophrenia showed altered microstates, specifically increased occipito-parietal and reduced fronto-temporal contributions compared to controls.
Benzodiazepine treatment correlated with changes in microstates but was controlled for in primary analysis, ensuring findings were not treatment-dependent.
No significant microstate differences were found in bipolar disorder and major depressive disorder compared to controls.

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Randomized trial reveals altered microstates in schizophrenia, indicating distinct brain activity disruptions.

Tavella et al. (2026) studied this question.

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