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This review aims to examine the limitations of CAR-T cells in treating myeloid malignancies and explore alternative CAR-cell therapies.

Exploring CAR cell therapies beyond CAR-T for myeloid malignancies

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This review aims to examine the limitations of CAR-T cells in treating myeloid malignancies and explore alternative CAR-cell therapies.
Review and analysis of current CAR-T cell therapy efficacy in myeloid malignancies.
Examination of emerging alternative CAR-engineered immune cells, including CAR-NK, CAR-NKT, and CAR-M cells.
Discussion on the unique properties and advantages of alternative CAR-cell therapies.
Traditional CAR-T cells show poor effectiveness and high toxicity in myeloid malignancies, particularly due to target antigen overlap with normal cells.
Alternative CAR-cell platforms demonstrate potential benefits like reduced safety concerns and better targeting of cancer cells.
Emerging therapies could provide more effective and safer treatment options for patients with these challenging cancers.

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Review highlights challenges and alternative CAR-cell treatments for myeloid malignancies, suggesting improved safety.

Li et al. (2026) studied this question.

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