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June 6, 2026NutrientsOpen Access

Efficacy, Safety, and Hematologic Recovery Following Intravenous Ferric Carboxymaltose in Patients with Iron Malabsorption-Related Iron Deficiency Anemia: A Prospective Clinical Study

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Authors

SSSilvia ScalamontiGPGiulia PivettaFSFrancesco Paolo Schiavone

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Overview

Prospective clinical study assesses recovery from iron deficiency anemia in patients with iron malabsorption, suggesting efficacy of IV ferric carboxymaltose treatment.

Key Points

  • This study aims to evaluate the efficacy, safety, and quality of life impact of intravenous ferric carboxymaltose in treating iron deficiency anemia due to iron malabsorption.
  • Single-center, prospective observational study with 37 adults having autoimmune gastritis, celiac disease, or gastric surgery-related IDA receiving IV ferric carboxymaltose.
  • Endpoints included safety tolerability, hemoglobin normalization for IDA recovery, and quality of life impact assessed through QoL-SF12 questionnaire at baseline and after 12 weeks.
  • Complete blood count and iron status were evaluated at baseline, 4 weeks, and 12 weeks post-treatment.
  • IDA recovery was achieved in 26 (70.3%) patients at 4 weeks and 29 (78.4%) at 12 weeks.
  • Significant increases in hemoglobin from 10.8 g/dL to 12.7 g/dL at 4 weeks and to 13.1 g/dL at 12 weeks (p < 0.05).
  • Only 2.7% experienced mild adverse events, indicating IV FCM is a safe treatment option.

Cite This Study

Scalamonti et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76c32https://doi.org/10.3390/nu18111807
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Also Consider

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  1. 1Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency2009 · 2,090 citations
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  5. 5Efficacy of gluten-free diet alone on recovery from iron deficiency anemia in adult celiac patients2001 · 154 citations