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July 7, 2026CureusOpen Access

Intravenous Ferric Carboxymaltose Versus Oral Ferrous Sulfate for Iron Deficiency Anemia: A Retrospective Cohort Study of Iron Store Repletion and Safety

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Authors

YOYasmine El OuafaIMInasse MourabitiNANabiha El Abdi

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Overview

Retrospective cohort study compares iron repletion and safety between IV and oral iron in patients with IDA, suggesting benefits of IV therapy.

Key Points

  • To compare the efficacy and safety of intravenous ferric carboxymaltose versus oral ferrous sulfate in iron deficiency anemia management.
  • Conducted a retrospective observational cohort study of 225 patients with IDA over three years.
  • Patients received either oral ferrous sulfate (n=185) or IV ferric carboxymaltose (n=40).
  • Primary endpoint was serum ferritin at three months post-treatment.
  • IV iron achieved significantly higher post-treatment ferritin levels (412.60±95.87 µg/L) compared to oral iron (8.68±4.38 µg/L; p<0.001).
  • Transfusion rates were 10.3% for oral and 17.5% for IV iron, with no significant difference (p=0.306).
  • Gastrointestinal adverse events occurred in 100% of oral iron recipients, while systemic reactions were reported in 50% of IV recipients.

Cite This Study

Ouafa et al. (2026) studied this question.

synapsesocial.com/papers/6a4c9687331bc25c9e5f3f84https://doi.org/10.7759/cureus.112040
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Efficacy, Safety, and Quality-of-Life Outcomes of Oral Ferrous Sulfate Versus Intravenous Ferric Carboxymaltose in the Management of Iron Deficiency Anemia During Pregnancy2026
  2. 2Retrospective Study Comparing Treatment Outcomes in Obstetric Patients With Iron Deficiency Anemia Treated With Intravenous Ferric Carboxymaltose Compared to Patients Who Did Not2024 · 1 citations
  3. 3Efficacy, Safety, and Hematologic Recovery Following Intravenous Ferric Carboxymaltose in Patients with Iron Malabsorption-Related Iron Deficiency Anemia: A Prospective Clinical Study2026
  4. 4Single-dose Intravenous Iron Versus Oral Iron for Treatment of Maternal Iron Deficiency Anemia: A Randomized Clinical Trial2025
  5. 5Randomized Controlled Trial of Intravenous Ferric Carboxymaltose vs Oral Iron to Treat Iron Deficiency Anemia After Variceal Bleed in Patients With Cirrhosis2024 · 6 citations