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June 6, 2026Annals of African Medicine

Comparative Efficacy, Safety, and Quality-of-Life Outcomes of Oral Ferrous Sulfate Versus Intravenous Ferric Carboxymaltose in the Management of Iron Deficiency Anemia During Pregnancy

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Authors

RCRiti ChakrabortyDr. D. Y. Patil Medical College, Hospital and Research CentreJKJayshree KulkarniDr. D. Y. Patil Medical College, Hospital and Research CentreAJAditi JhaDr. D. Y. Patil Medical College, Hospital and Research Centre

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Overview

Randomized trial compares efficacy and safety of oral vs IV iron treatments in pregnant women with iron deficiency anemia, indicating a preferred IV option.

Key Points

  • This research aims to compare the efficacy and safety of oral ferrous sulfate and IV ferric carboxymaltose for treating iron deficiency anemia during pregnancy.
  • A comparative analysis involving 60 pregnant women with iron deficiency anemia, randomized to receive either oral ferrous sulfate or IV ferric carboxymaltose.
  • Measured outcomes included hemoglobin changes, serum ferritin, packed cell volume, fatigue scores, and adverse effect profiles.
  • IV ferric carboxymaltose lead to a mean hemoglobin rise of 3.56 g/dL compared to 2.52 g/dL in the oral group (P < 0.001).
  • Serum ferritin levels significantly increased to 73.13 ng/mL in the IV group versus 22.70 ng/mL in the oral group (P < 0.001).
  • IV iron improved fatigue scores more effectively than oral iron (P < 0.001), with fewer gastrointestinal side effects.

Cite This Study

Chakraborty et al. (2026) studied this question.

synapsesocial.com/papers/6a23b9f271a5da9775e75ae8https://doi.org/10.4103/aam.aam_18_26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Intravenous Ferric Carboxymaltose Versus Oral Ferrous Sulfate for Iron Deficiency Anemia: A Retrospective Cohort Study of Iron Store Repletion and Safety2026
  2. 2Injectable Ferric Carboxy Maltose Versus Oral Ferrous Fumerrate in Treatment of Iron Deficiency Anaemia in Pregnancy- A Randomized Controlled Trial2025 · 1 citations
  3. 3Intravenous Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Postpartum Anemia2007 · 246 citations
  4. 4Single-dose Intravenous Iron Versus Oral Iron for Treatment of Maternal Iron Deficiency Anemia: A Randomized Clinical Trial2025
  5. 5Intravenous Ferumoxytol Compared With Oral Ferrous Sulfate for Iron Deficiency Anemia in Pregnancy2026 · 1 citations