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August 1, 2007Obstetrics and Gynecology

Intravenous Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Postpartum Anemia

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Authors

DWDavid B. Van Wyck MMMark G. Martens MSMelvin H. Seid

Discussion

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Overview

Randomized trial demonstrates faster and higher hemoglobin recovery with intravenous ferric carboxymaltose in postpartum anemia, indicating more effective replenishment than oral iron.

Key Points

To evaluate the efficacy and speed of rapid, high-dose intravenous ferric carboxymaltose compared with oral ferrous sulfate in treating postpartum anemia.
Randomized controlled trial (NCT00396292) in women within 10 days postpartum with hemoglobin levels ≤10.0 g/dL.
Participants received either intravenous ferric carboxymaltose (≤1,000 mg over 15 minutes weekly, mean total dose 1,403.1 mg; n=174) or oral ferrous sulfate (325 mg three times daily for 6 weeks; n=178).
Patients receiving intravenous iron achieved a hemoglobin increase ≥2.0 g/dL significantly faster than those receiving oral iron (7.0 vs. 14.0 days, P<.001), while overall achievement of this threshold was 96.4% vs. 94.1% (P=.443).
Intravenous ferric carboxymaltose led to higher rates of achieving a hemoglobin increase ≥3.0 g/dL (86.3% vs. 60.4%, P<.001) and reaching normal hemoglobin >12.0 g/dL (90.5% vs. 68.6%, P<.001), with no serious adverse drug reactions.

Cite This Study

Wyck et al. (2007) studied this question.

synapsesocial.com/papers/6a79e194b9dd6cc1fe0dacd2 https://doi.org/10.1097/01.aog.0000275286.03283.18

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August 1, 2007Obstetrics and Gynecology

Intravenous Ferric Carboxymaltose Compared With Oral Iron in the Treatment of Postpartum Anemia

View Full Paper

Ask AI

Bookmark

Authors

DWDavid B. Van Wyck MMMark G. Martens MSMelvin H. Seid

Discussion

Member takes

Overview

Randomized trial demonstrates faster and higher hemoglobin recovery with intravenous ferric carboxymaltose in postpartum anemia, indicating more effective replenishment than oral iron.

Key Points

To evaluate the efficacy and speed of rapid, high-dose intravenous ferric carboxymaltose compared with oral ferrous sulfate in treating postpartum anemia.
Randomized controlled trial (NCT00396292) in women within 10 days postpartum with hemoglobin levels ≤10.0 g/dL.
Participants received either intravenous ferric carboxymaltose (≤1,000 mg over 15 minutes weekly, mean total dose 1,403.1 mg; n=174) or oral ferrous sulfate (325 mg three times daily for 6 weeks; n=178).
Patients receiving intravenous iron achieved a hemoglobin increase ≥2.0 g/dL significantly faster than those receiving oral iron (7.0 vs. 14.0 days, P<.001), while overall achievement of this threshold was 96.4% vs. 94.1% (P=.443).
Intravenous ferric carboxymaltose led to higher rates of achieving a hemoglobin increase ≥3.0 g/dL (86.3% vs. 60.4%, P<.001) and reaching normal hemoglobin >12.0 g/dL (90.5% vs. 68.6%, P<.001), with no serious adverse drug reactions.

Cite This Study

Wyck et al. (2007) studied this question.

synapsesocial.com/papers/6a79e194b9dd6cc1fe0dacd2 https://doi.org/10.1097/01.aog.0000275286.03283.18

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