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June 6, 2026NephrologyOpen Access

Late Presentation of de Novo Proliferative Glomerulonephritis With Monoclonal IgG Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course

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Authors

HDHayley J. DuxburyDBDavid A. BrownALAdrian Ys Lee

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Overview

Randomized trial shows late onset of kidney dysfunction in renal allograft, indicating need for timely treatment.

Key Points

  • This research aims to document a rare case of late-onset proliferative glomerulonephritis in a renal allograft.
  • Patient presented 10.5 years post simultaneous pancreas-kidney transplantation
  • Renal biopsy confirmed electron-dense deposits and immunofluorescence analysis identified IgG3 lambda light chains
  • Treatment administered included prednisone and rituximab
  • Ongoing improvement in proteinuria and kidney function post-treatment
  • This case represents the latest known instance of de novo PGNMID after kidney transplantation
  • Diagnosis confirmed absence of bone marrow plasma cell or lymphoid clone

Cite This Study

Duxbury et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76d44https://doi.org/10.1111/nep.70225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Fresh Perspective on Monoclonal Gammopathies of Renal Significance2021 · 21 citations
  2. 2An update of proliferative glomerulonephritis with monoclonal immunoglobulin deposits2021 · 26 citations
  3. 3Paraffin Immunofluorescence: A Valuable Ancillary Technique in Renal Pathology2018 · 90 citations
  4. 4Spectrum of renal diseases caused by monoclonal immunoglobulin: experience from an Australian tertiary referral centre over a 10-year period2025 · 1 citations
  5. 5A Review on the Diagnosis and Treatment of Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits2022 · 13 citations