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June 28, 2026CureusOpen Access

De Novo Proliferative Glomerulonephritis With Monoclonal Immunoglobulin Deposits (PGNMID) in a Renal Transplant Recipient

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Authors

RMRam Prabahar MurugesanSSSathiyan SivanandamJJJayanivash Jayam

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Overview

Case report reveals unique de novo proliferative glomerulonephritis in a renal transplant recipient, indicating complexity in management.

Key Points

  • This report aims to describe a rare case of de novo proliferative glomerulonephritis with monoclonal immunoglobulin deposits in a renal transplant recipient.
  • Documented a case of a 50-year-old patient post-kidney transplant with PGNMID developed three years post-surgery.
  • Utilized immunofluorescence for kidney biopsy analysis and positron emission tomography-computed tomography (PET-CT) for further assessment.
  • Administered Rituximab as an empirical therapy targeting a potential B-cell clone.
  • The transplant kidney biopsy showed mesangial hypercellularity with IgG and kappa light chain deposition.
  • Despite treatment, no specific clone contributing to monoclonal gammopathy was identified.
  • At last follow-up, graft function remained stable, although follow-up duration was limited.

Cite This Study

Murugesan et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb4561bb0a67205c6e76https://doi.org/10.7759/cureus.111522
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Late Presentation of <i>de Novo</i> Proliferative Glomerulonephritis With Monoclonal <scp>IgG</scp> Deposits in a Renal Allograft: A Rare Case With an Unusual Clinical Course2026
  2. 2Proliferative Glomerulonephritis With Monoclonal IgG Deposits: Another Unusual Presentation2024 · 3 citations
  3. 3Proliferative glomerulonephritis with monoclonal immunoglobulin deposits with severe acute kidney injury successfully managed by clone-directed therapy: a case report2026 · 1 citations
  4. 4A Case Series of Monoclonal Immunoglobulin-Depositing Proliferative Glomerulonephritis2024
  5. 5Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits: An Immunologic Crossroads2026