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April 20, 2026˜The œNephron journals/Nephron journals

Proliferative glomerulonephritis with monoclonal immunoglobulin deposits with severe acute kidney injury successfully managed by clone-directed therapy: a case report

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Authors

SMShohei MaékawaSYShinya YamamotoTKTatsuaki Kosaka

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Overview

A case report demonstrates clone-directed therapy's effect on recurrent kidney injury in PGNMID, indicating promising outcomes.

Key Points

  • This report aims to illustrate the management of recurrent proliferative glomerulonephritis with monoclonal immunoglobulin deposits leading to severe acute kidney injury.
  • Case presentation of a 60-year-old man diagnosed with PGNMID without detectable clones.
  • Treatment included glucocorticoids followed by clone-directed therapies with daratumumab and bortezomib.
  • Assessment involved urine protein/creatinine ratio and kidney biopsies.
  • Initial treatment with glucocorticoids yielded partial response with improved urinary parameters.
  • A relapse occurred after viral enteritis, resulting in severe acute kidney injury requiring dialysis.
  • Clone-directed therapy led to cessation of dialysis and further improvement in kidney function.

Cite This Study

Maékawa et al. (2026) studied this question.

synapsesocial.com/papers/69e5c36103c293991402920bhttps://doi.org/10.1159/000552029
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Also Consider

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  1. 1Proliferative Glomerulonephritis With Monoclonal IgG Deposits: Another Unusual Presentation2024 · 3 citations
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  4. 4Safety and Efficacy of Daratumumab in Patients with Proliferative GN with Monoclonal Immunoglobulin Deposits2021 · 74 citations
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