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June 6, 2026Beni-Suef University Journal of Basic and Applied SciencesOpen Access

The shift from 2D to 3D cell culture in neurobiology: implications for precision medicine and organ-on-chip technologies

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Authors

FMFarnam Gholipour Maralan

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Overview

Review explores technological advances in 3D models highlighting disease modeling and drug discovery implications.

Key Points

  • The aim is to discuss the transition from 2D to 3D cell culture systems and their relevance in neurobiology and precision medicine.
  • Explored technological advancements in 3D systems including neural organoids and microfluidic platforms.
  • Discussed integration of patient-derived induced pluripotent stem cells for personalized drug screening.
  • Examined mechanotransduction and blood-brain barrier contributions to disease progression.
  • 3D models provide realistic representations of human CNS conditions, unlike traditional 2D models.
  • Highlighting disease phenotypes like amyloid-beta aggregation improves modeling accuracy.
  • Enhanced fidelity in drug screening supports more effective precision medicine approaches.

Cite This Study

Farnam Gholipour Maralan (2026) studied this question.

synapsesocial.com/papers/6a23bb7971a5da9775e76e3dhttps://doi.org/10.1186/s43088-026-00790-7
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