Review finds melatonin may prevent migraines and aid cluster headaches while improving sleep.
This review summarizes the current evidence regarding the use of melatonin in sleep disorders, circadian rhythm disturbances, migraine prevention, and cluster headache management. Melatonin is a neurohormone involved in the regulation of sleep-wake cycles and circadian rhythms. Beyond its role in sleep medicine, growing evidence suggests potential benefits in selected neurological disorders, particularly migraine and cluster headache. Prepared by Dr. Radion. The article discusses mechanisms of action, clinical applications, dosing strategies, safety considerations, adverse effects, and practical recommendations based on published clinical trials and review articles. Evidence from randomized controlled trials indicates that melatonin may provide benefits in migraine prevention and may be useful as an adjunctive treatment in cluster headache, while maintaining a favorable safety profile. This publication is intended for physicians, healthcare professionals, researchers, and patients interested in evidence-based approaches to sleep disorders and headache management.
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