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June 9, 2026Neurology

Melatonin for Migraine Prevention in Children and Adolescents: A Systematic Review of Randomized Controlled Trials (P10-15.016)

Yara Shaalan Shams Albarari Rewan Ramadan Ainaa A. Alzamari Noon Elimam Rahaf Mogahed Nourhan Elmekkawi Arwa Abdelaziz Mostafa Eman Fathy

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Key Points

This systematic review aims to evaluate how effective and safe melatonin is for preventing migraines in children and adolescents.
Conducted a systematic review of randomized controlled trials on melatonin for migraine prevention.
Included studies focused on children and adolescents experiencing migraines.
Assessed both efficacy and safety outcomes across the trials.
Melatonin showed effectiveness in reducing headache frequency in children and adolescents.
The safety profile of melatonin was favorable, with few adverse effects reported.

Implication

Systematic review evaluates the efficacy and safety of melatonin for migraine prevention in adolescents, indicating a potential treatment option.

Abstract

To evaluate the efficacy and safety of melatonin for the prevention of migraine in children and adolescents.

Discussion

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Cite This Study

Shaalan et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf3d6faef96ed7f05643a https://doi.org/10.1212/wnl.0000000000212946

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