What is the clinical evidence from this study?

Study design: Editorial. Population: Pulmonary arterial hypertension. Intervention: High cardiac output.

What question did this study set out to answer?

This research investigates the relationship between high cardiac output and outcomes in patients with pulmonary arterial hypertension.

June 6, 2026European Respiratory Journal

The challenging combination of a high cardiac output and pulmonary arterial hypertension

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Key result

A higher than normal cardiac output in patients with pulmonary arterial hypertension may be deleterious.

Population

Patients with pulmonary arterial hypertension (PAH)

Design

Editorial

Authors

RNRobert NaeijeGeneral Cardiology LSLaurent SavaleInserm

Discussion

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Implication

Highlights that contrary to typical right heart failure patterns, high cardiac output in PAH may be associated with deleterious outcomes.

Key Points

This research investigates the relationship between high cardiac output and outcomes in patients with pulmonary arterial hypertension.
Analyzed data from patients with pulmonary arterial hypertension and their cardiac outputs.
Evaluated afterload-induced right ventricular failure and related metrics.
Assessed prognostic factors such as stroke volume and right atrial pressure.
Higher than normal cardiac output in PAH patients was associated with poorer outcomes.
Patients with increased pulmonary vascular resistance exhibited lower stroke volume.
The data suggests that interventions aimed at increasing cardiac output may not always be beneficial.

Structured PICO

Population

Patients with pulmonary arterial hypertension (PAH)

Highlights that contrary to typical right heart failure patterns, high cardiac output in PAH may be associated with deleterious outcomes.

Cite This Study

Naeije et al. (2026) conducted an editorial in Pulmonary arterial hypertension. High cardiac output was evaluated. A higher than normal cardiac output in patients with pulmonary arterial hypertension may be deleterious.

synapsesocial.com/papers/6a23bc2a71a5da9775e7781e https://doi.org/10.1183/13993003.02698-2025

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The challenging combination of a high cardiac output and pulmonary arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The challenging combination of a high cardiac output and pulmonary arterial hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider