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June 6, 2026International Journal of Molecular SciencesOpen Access

Magnetically Targeted Drug Transport Across a Tumor Cell Membrane Under Magnetic Field Gradients

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Authors

MKM.S. KovačevićRDRelja DragnicVMVladimir Marković

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Overview

Theoretical model examines magnetic targeting's effects on drug delivery in tumor cells, suggesting improvement in transport efficiency.

Key Points

  • To quantify the impact of magnetic targeting on drug transport across tumor cell membranes using a theoretical and numerical model.
  • Developed a theoretical model for drug transport using an advection-diffusion equation for extracellular drug movement.
  • Utilized finite-difference schemes to solve transport equations under spherical symmetry with specified magnetic parameters.
  • Compared drug delivery between tumor and healthy cells by varying membrane permeability and uptake rates.
  • Magnetophoretic drift significantly enhances near-membrane drug accumulation, improving effective transmembrane flux.
  • The model predicts a greater delivery advantage in tumor cells due to magnetic targeting, amplifying existing biological differences.
  • The magnetic Peclet number is identified as the critical factor influencing the shift from diffusion-dominated to drift-enhanced transport.

Cite This Study

Kovačević et al. (2026) studied this question.

synapsesocial.com/papers/6a23bc2a71a5da9775e77849https://doi.org/10.3390/ijms27115098
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