(698) Urolithiasis as a Potential Risk Factor for Erectile Dysfunction: A Retrospective Cohort Study

Introduction Erectile dysfunction (ED) is strongly associated with cardiometabolic disorders such as obesity, hypertension, and diabetes mellitus. Similarly, urolithiasis is linked to metabolic syndrome and systemic inflammation. Given these overlapping risk factors, it is plausible that ED and urolithiasis may share a pathophysiological relationship. However, few studies have investigated this potential association. Objective This study aimed to evaluate the relationship between erectile dysfunction and urolithiasis by comparing IIEF-5 scores between patients with and without urolithiasis. Methods We conducted a retrospective case-control study including 38 male patients diagnosed with urolithiasis and 32 male controls without stone disease who were admitted to our clinic. Patients with severe cardiovascular disease, endocrine disorders, or neurological conditions affecting erectile function were excluded. Erectile function was evaluated using the International Index of Erectile Function (IIEF-5). Clinical and demographic data were collected from medical records, and appropriate statistical analyses were performed to compare variables between groups. Results Erectile dysfunction was observed in 17 of 38 patients with urolithiasis (44.7%), whereas only 6 of 32 controls (18.8%) reported mild ED and none had moderate or severe ED. Among patients with urolithiasis, 6 (15.8%) had mild ED, 5 (13.2%) had moderate ED, and 6 (15.8%) had severe ED. The prevalence and severity of ED were significantly higher in the urolithiasis group than in the controls (p < 0.05). Conclusions ED was significantly more prevalent among patients with urolithiasis, suggesting a shared systemic background. Routine assessment of erectile function should be considered in men with urolithiasis to facilitate early detection and guide lifestyle and metabolic management. Disclosure No