Key result
Insulin-induced vasodilation is impaired in small coronary arteries of Zucker obese rats due to increased reactive oxygen species production by vascular NADPH oxidase.
Population
Isolated small coronary arteries of Zucker obese and control Zucker lean rats
Comparison
Insulin with or without SOD, N-nitro-L-arginine… vs Zucker lean (ZL) rats and baseline responses
Design
Preclinical
Authors
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Hypothesis-generating for NADPH oxidase targeting in obese coronary dysfunction; leaves open human translation.
Insulin resistance impairs insulin-induced vasodilation in small coronary arteries via increased ROS production by vascular NADPH oxidase, which reduces NO bioavailability.
Katakam et al. (2005) studied Insulin resistance and obesity. Insulin vs. Zucker lean rats (control) was evaluated on Insulin-induced vasodilation in isolated small coronary arteries. Insulin-induced vasodilation is impaired in small coronary arteries of Zucker obese rats due to increased reactive oxygen species production by vascular NADPH oxidase.
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