Key result
Young, normal-weight women with PCOS had significantly lower flow-mediated dilation (14.3% vs 18.1%) and higher intima-media thickness (0.53 mm vs 0.39 mm) than healthy controls (P<0.05).
Why the study?
Does polycystic ovary syndrome (PCOS) impair endothelial structure and function in young normal-weight women?
Population
60 young normal-weight women, comprising 30 with polycystic ovary syndrome without additional metabolic or…
Comparison
Polycystic ovary syndrome (PCOS) diagnosis vs Healthy age- and BMI-matched controls
Design
Case-control
Authors
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May indicate early vascular risk in young normal-weight PCOS; leaves open need for prospective outcome studies before clinical adoption.
Case-Control (n=60)
Does polycystic ovary syndrome (PCOS) impair endothelial structure and function in young normal-weight women?
Absolute Event Rate: 14.3% vs 18.1%
p-value: p=<0.05
Young, normal-weight women with PCOS exhibit early impairment of endothelial structure and function compared to healthy controls, indicating increased early cardiovascular risk.
Orio et al. (2004) conducted a case-control in Polycystic ovary syndrome (n=60). Polycystic ovary syndrome vs. Healthy women matched for age and body mass index was evaluated on Flow-mediated dilation (p=<0.05). Young, normal-weight women with PCOS had significantly lower flow-mediated dilation (14.3% vs 18.1%) and higher intima-media thickness (0.53 mm vs 0.39 mm) than healthy controls (P<0.05).
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