Key result
Short-term C-peptide infusion in type 1 diabetic patients significantly increased myocardial blood volume (from 6.6 to 8.1 a.u., P<0.02) and blood flow index (from 3.3 to 5.3, P<0.05).
Why the study?
Does C-peptide infusion improve myocardial blood flow and function in patients with type 1 diabetes?
Population
8 patients with type 1 diabetes and 8 age-matched healthy volunteers as control subjects
Comparison
C-peptide infusion (6 pmol x kg x min) during 60… vs Saline infusion during 60 min
Design
RCT, randomized crossover protocol, double-blind
Follow-up
60 min
Authors
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May improve myocardial perfusion in type 1 diabetes; extends randomized evidence of C-peptide effects to coronary circulation.
RCT (n=16)
Double-blind
Randomized crossover
Does C-peptide infusion improve myocardial blood flow and function in patients with type 1 diabetes?
Absolute Event Rate: 8.1% vs 6.6%
p-value: p=<0.02
Short-term C-peptide replacement improves impaired myocardial function and perfusion in patients with type 1 diabetes.
Hansen et al. (2002) conducted an RCT in Type 1 diabetes (n=16). C-peptide vs. Saline was evaluated on Myocardial blood volume (SI(max)) (p=<0.02). Short-term C-peptide infusion in type 1 diabetic patients significantly increased myocardial blood volume (from 6.6 to 8.1 a.u., P<0.02) and blood flow index (from 3.3 to 5.3, P<0.05).
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