Key result
Higher thigh muscle fat infiltration linked to ~4% greater risk of vascular events.
Why the study?
The study aimed to explore the associations between thigh muscle fat density and vascular events.
Does higher thigh muscle fat density increase the risk of vascular events in adults without baseline cardiovascular disease?
Cohort (n=3,595)
No
Does higher thigh muscle fat density increase the risk of vascular events in adults without baseline cardiovascular disease?
Hazard Ratio: 1.04 (95% CI 1.02–1.06)
p-value: p=<0.001
Higher thigh muscle fat infiltration, measured by the LDM/NDM ratio on CT, is independently associated with an increased risk of developing vascular events in Korean adults.
May flag higher vascular risk on CT scans; hypothesis-generating and should not yet change practice.
Background We aimed to explore the associations between thigh muscle fat density and vascular events. Methods A total of 3,595 adults (mean age, 57.2 years; women, 1,715 [47.7%]) without baseline cardiovascular events from the Korean Atherosclerosis Study-2 were included. Muscle and fat area at the mid-thigh level were measured by computed tomography (CT) using the following Hounsfield Unit range: 0–30 for low density muscle (LDM); 31–100 for normal density muscle (NDM); and − 250 to − 50 for fat. Results During a median follow-up period of 11.8 (4.3–13.9) years, vascular events occurred in 11.6% of men and 5.9% of women. Individuals with vascular events had a larger LDM area (men: 48.8 ± 15.5 cm 2 vs. 44.6 ± 14.5 cm 2 ; women: 39.4 ± 13.2 cm 2 vs. 35.0 ± 11.8 cm 2 , both P < 0.001) compared with those who did not have vascular events during the follow-up of at least 5 years. The LDM/NDM ratio was also independently associated with vascular events after adjusting for cardiometabolic risk factors. Moreover, the LDM/NDM ratio improved the prognostic value for vascular events when added to conventional risk factors. Conclusions The current study suggests that a higher thigh muscle fat infiltration is associated with an increased risk of developing vascular events among Korean adults.
No takes yet. Share an insight, caveat, or question.
Choe et al. (2024) conducted a cohort in Cardiometabolic risk factors without baseline cardiovascular events (n=3,595). Higher mid-thigh low density to normal density muscle (LDM/NDM) ratio vs. Lower LDM/NDM ratio was evaluated on Vascular events (HR 1.04, 95% CI 1.02-1.06, p=<0.001). Higher thigh muscle fat infiltration, measured by the LDM/NDM ratio, was independently associated with an increased risk of developing vascular events in both men (HR 1.04) and women (HR 1.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: