Key result
Preadipocytes from female obese donors exhibited significantly higher mitochondrial to glycolytic activity compared to males (p=0.036), maintaining enhanced mitochondrial flexibility.
Why the study?
Clinical phenotypes of obesity differ by sex, and higher expression of mitochondria-related genes in female white adipose tissue suggested gender differences in (pre-)adipocyte bioenergetics.
Population
(Pre-)adipocytes from 10 male and 10 female deeply-phenotyped obese donors
Comparison
Female vs male donors under hypo-, normo-, and hyperglycemic and insulin-stimulated conditions
Design
In vitro comparative study
Authors
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Sex differences in preadipocyte bioenergetics may guide targeted obesity research; hypothesis-generating and should not yet alter clinical practice.
Observational (n=20)
p-value: p=0.036
Preadipocytes from obese females exhibit higher mitochondrial flexibility and distinct bioenergetic responses to glucose and insulin compared to males, highlighting sex-specific metabolic phenotypes.
Keuper et al. (2018) conducted an observational in Obesity (n=20). Female sex vs. Male sex was evaluated on Mitochondrial to glycolytic activity (OCR/ECAR ratio) in preadipocytes (p=0.036). Preadipocytes from female obese donors exhibited significantly higher mitochondrial to glycolytic activity compared to males (p=0.036), maintaining enhanced mitochondrial flexibility.
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