Key result
Female mice on high-fat diets exhibit greater visceral adipose angiogenesis than males, linked to preserved metabolism.
Why the study?
Does a high-fat diet induce distinct angiogenic capacities and metabolic responses in male versus female mice?
Population
Age-matched male and female mice
Comparison
High-fat obesogenic diet for 16 weeks vs Normal chow diet
Design
Preclinical
Follow-up
16 weeks
Authors
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Does not support clinical practice changes; leaves open whether sex differences in adipose angiogenesis protect metabolic health in humans.
Does a high-fat diet induce distinct angiogenic capacities and metabolic responses in male versus female mice?
Female mice exhibit greater angiogenesis in visceral adipose tissue than males in response to a high-fat diet, which is associated with preserved metabolic homeostasis.
Rudnicki et al. (2018) studied Diet-induced obesity (n=37). High-fat diet vs. Low-fat diet (11% kcal from fat) was evaluated on Capillary content and expression of angiogenic regulators in perigonadal white adipose tissue. Female mice fed a high-fat diet exhibited greater levels of pro-angiogenic factors and vascularity in visceral adipose tissue than males, which was associated with preserved metabolic homeostasis.
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