Key result
High fat diet impairs endothelium-dependent vasorelaxation by ~11% in male mice but not females.
Why the study?
The sex-specific effects of a high fat diet on aortic inflammation and function in mouse models of obesity were unclear.
Does a high fat diet cause sex-specific effects on aortic inflammation and dysfunction in C57BL/6J mice?
Population
6-week-old male and female C57BL/6 mice
Comparison
High fat diet vs normal chow diet
Design
Animal experimental study
Follow-up
10 weeks
Authors
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Sex differences in mouse endothelial dysfunction should not yet guide clinical care; leaves open human translation of diet-induced vascular effects by sex.
Does a high fat diet cause sex-specific effects on aortic inflammation and dysfunction in C57BL/6J mice?
Absolute Event Rate: 76.6% vs 86.1%
p-value: p=0.003
A 10-week high-fat diet induces metabolic disturbances and endothelial dysfunction primarily in male mice, highlighting biological sex as a key determinant of vascular disease severity in early obesity models.
Tran et al. (2023) studied Obesity and vascular dysfunction. High fat diet vs. Normal chow diet was evaluated on Maximal endothelium-dependent vasorelaxation (Rmax) to acetylcholine in males (p=0.003). A 10-week high fat diet impaired maximal endothelium-dependent vasorelaxation in male mice (76.6% vs 86.1%, P=0.003) but not females, highlighting sex-specific vascular disease severity.
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