Why the study?
Perivascular adipose tissue expansion promotes inflammation and vascular dysfunction in metabolic syndrome, but the sexual dimorphisms of perivascular adipose tissue are poorly understood.
Does a high-fat, high-sugar, high-salt diet induce sex-specific changes in aortic function and inflammation in a mouse model of metabolic syndrome?
Population
Six-week-old male and female C57BL/6 mice
Comparison
High-fat, high-sugar, and high-salt diet vs normal chow diet
Design
Preclinical animal study
Follow-up
10 weeks
Key result
A high-fat, high-sugar, and high-salt diet induced metabolic syndrome and caused contrasting effects on vascular function with and without perivascular adipose tissue between male and female mice.
Authors
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May suggest sex-specific vascular responses in metabolic syndrome models; leaves open human translation and clinical relevance.
Does a high-fat, high-sugar, high-salt diet induce sex-specific changes in aortic function and inflammation in a mouse model of metabolic syndrome?
p-value: p=<0.05
A novel diet-induced metabolic syndrome mouse model reveals significant sexual dimorphism in how perivascular adipose tissue regulates vascular function.
Tran et al. (2025) studied Metabolic syndrome. High-fat diet with high sugar and salt (HFSS) vs. Normal chow diet (NCD) was evaluated on Weight gain, fasting blood glucose, systolic blood pressure, aortic fibrosis, and perivascular adipocyte cross-sectional area (p=<0.05). A high-fat, high-sugar, and high-salt diet induced metabolic syndrome and caused contrasting effects on vascular function with and without perivascular adipose tissue between male and female mice.