Key result
A high-fat, high-sucrose, high-salt diet induced left ventricular chamber dilation in both male (38% increase) and female (34% increase) mice, while inducing heart hypertrophy exclusively in males.
Why the study?
Does a high-fat, high-sucrose, high-salt diet induce gender-specific cardiovascular remodeling in C57BL/6J mice?
Population
Male and female C57BL/6J mice at 3 months of age (n=12-15/group)
Comparison
Modified AIN93M diet rich in saturated fat… vs Standard AIN93M diet for 12 weeks
Design
Preclinical, randomly allocated into four groups
Follow-up
12 weeks
Authors
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Preclinical data on sex-specific remodeling; leaves open human dietary relevance and mechanisms.
Does a high-fat, high-sucrose, high-salt diet induce gender-specific cardiovascular remodeling in C57BL/6J mice?
p-value: p=<0.001
A high-fat, high-sucrose, high-salt diet induces cardiovascular remodeling in mice without causing obesity or diabetes, with significant sexual dimorphism in heart hypertrophy and arterial remodeling.
Pereira‐Silva et al. (2018) studied Cardiovascular remodeling. High-fat, high-sucrose, high-salt (HFSS) diet vs. AIN93M control diet was evaluated on Left ventricle lumen diameter (p=<0.001). A high-fat, high-sucrose, high-salt diet induced left ventricular chamber dilation in both male (38% increase) and female (34% increase) mice, while inducing heart hypertrophy exclusively in males.