Key result
A high-fat, high-sucrose, and high-salt diet for 12 weeks induced cardiovascular remodeling in C57BL/6J mice without obesity or diabetes, with sexual dimorphism in adiposity and heart hypertrophy.
Why the study?
The influence of gender on modern diet-induced cardiovascular disease had not been explored in animal models.
Does a high-fat, high-sucrose, and high-salt diet induce sexually dimorphic cardiovascular remodeling in C57BL/6J mice?
Population
Male and female C57BL/6J mice
Comparison
HFSS diet vs AIN93M diet
Design
Animal study
Follow-up
12 weeks
Authors
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Animal data do not inform human diets; leaves open sex-specific mechanisms of diet-induced remodeling for translational study.
Does a high-fat, high-sucrose, and high-salt diet induce sexually dimorphic cardiovascular remodeling in C57BL/6J mice?
A high-fat, high-sucrose, and high-salt diet induces cardiovascular remodeling in mice without causing obesity or diabetes, with distinct structural changes between males and females.
Pereira‐Silva et al. (2019) studied Cardiovascular remodeling. High-fat, high-sucrose, and high-salt (HFSS) diet vs. AIN93M diet was evaluated on Cardiovascular remodeling (body mass, adiposity, heart hypertrophy, arterial remodeling). A high-fat, high-sucrose, and high-salt diet for 12 weeks induced cardiovascular remodeling in C57BL/6J mice without obesity or diabetes, with sexual dimorphism in adiposity and heart hypertrophy.