Key result
High-fat diet-fed Dahl SS rats of both sexes were largely protected from vascular dysfunctions, though male PVAT became more fibrotic and lost the ability to assist in arterial stress relaxation.
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In a Dahl SS rat model, high-fat diet-induced hypertension does not cause typical vascular dysfunction, though sex-specific changes in perivascular adipose tissue (PVAT) occur in males.
Although the aorta exhibits medial hypertrophy in response to HF diet-induced hypertension, it did not exhibit hyperresponsive contraction to an α-adrenergic agonist nor endothelial cell dysfunction; this was true for both sexes. Unlike other hypertension models, PVAT around aorta from (male) rats on the HF diet retained significant anticontractile activity. PVAT around aorta of the male on a HF diet was modestly more fibrotic and lost the ability to assist in arterial stress relaxation.
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Watts et al. (2021) studied High-fat diet-induced hypertension. High-fat diet was evaluated on Vascular dysfunctions (hyperresponsive contraction and endothelial cell dysfunction). High-fat diet-fed Dahl SS rats of both sexes were largely protected from vascular dysfunctions, though male PVAT became more fibrotic and lost the ability to assist in arterial stress relaxation.
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