Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 17, 2021Frontiers in PhysiologyOpen Access

A high-fat diet induced sex-specific phenotypic changes in T cell and macrophage subtypes within perivascular adipose tissues that preceded the development of hypertension in Dahl salt-sensitive rats.

View Full Paper
Ask AI
Bookmark
Share

Population

Male and female Dahl S rats

Comparison

High-fat diet (60% calories from fat) from weaning vs Regular diet (10% calories from fat) from weaning

Design

Preclinical

Follow-up

24 weeks

Key result

A high-fat diet induced sex-specific phenotypic changes in T cell and macrophage subtypes within perivascular adipose tissues that preceded the development of hypertension in Dahl salt-sensitive rats.

Authors

RKRamya K. KumarYYYongliang YangACAndres Contreras

Discussion

Loading...

Member takes

Overview

Does not support clinical practice changes; leaves open whether sex-specific perivascular immune shifts drive hypertension in humans.

Structured PICO

P
Population
Male and female Dahl salt-sensitive rats fed a control or high-fat diet for up to 24 weeks to evaluate immune cell changes in perivascular adipose tissue preceding hypertension.
I
Intervention
High-fat diet (60% calories from fat) from weaning
C
Comparator
Regular diet (10% calories from fat) from weaning
O
Outcome
Phenotypic changes in immune cell composition (macrophages, T cells, neutrophils, mast, B and NK cells) and gene expression in perivascular adipose tissues (PVATs)surrogate

In a rat model, high-fat diet induces sex-specific immune cell changes in perivascular adipose tissue that precede the onset of hypertension.

Limitations

  • Dendritic cells and eosinophils could not be included due to lack of reliable flow cytometry markers in rats.
  • The origin of the specific immune cell subtypes identified in PVATs with HFD is not interpretable.
  • Factors linked to sex-differences in hypertension such as gonadal hormones, cytokines, and adipokines were not measured.
  • Estrous staging or ovariectomizing females were not performed.
  • RNA-sequencing at 10- and 17-week time points was not performed.
  • The functional roles or consequences of the dynamic immune cell changes in PVAT require further study.

Cite This Study

Kumar et al. (2021) studied High-fat diet-induced hypertension. High-fat diet vs. Control diet (10% kcal from fat) was evaluated on Differentially expressed genes and immune cell subtype counts in perivascular adipose tissue. A high-fat diet induced sex-specific phenotypic changes in T cell and macrophage subtypes within perivascular adipose tissues that preceded the development of hypertension in Dahl salt-sensitive rats.

synapsesocial.com/papers/6aae49c5c1521a6d490ccb95https://doi.org/10.3389/fphys.2021.616055
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T lymphocytes mediate hypertension and kidney damage in Dahl salt-sensitive rats2010 · 203 citations
  2. 2Gut Microbiota Promote Angiotensin II–Induced Arterial Hypertension and Vascular Dysfunction2016 · 385 citations
  3. 3Eosinophils are key regulators of perivascular adipose tissue and vascular functionality2017 · 100 citations
  4. 4Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease2008 · 110 citations
  5. 5Deficiency of T-regulatory cells exaggerates angiotensin II-induced microvascular injury by enhancing immune responses2015 · 98 citations