Key result
In living human tissues, the median distance of peri-renal sympathetic nerve fibers from the renal artery lumen was 1.50 mm, with 16% of fibers located beyond 3 mm, deeper than conventional renal denervation lesion depths.
Why the study?
Renal denervation lowers blood pressure in resistant hypertension, but the detailed anatomic conformation of peri-renal arterial sympathetic nerve fibers in living human specimens required investigation.
Cross-Sectional (n=28)
No
A substantial proportion of peri-renal sympathetic nerve fibers are located deeper than the typical lesion depth created by conventional catheter-based renal denervation, potentially explaining variable clinical efficacy.
May limit conventional renal denervation reach; leaves open whether deeper ablation improves hypertension control.
Renal denervation using radiofrequency catheter ablation is known to eliminate the renal sympathetic nerve and to lower blood pressure in patients with resistant hypertension. We sought to investigate the detailed anatomic conformation of the peri-renal arterial sympathetic nerve fibers with living human specimens. Peri-renal arterial tissue was harvested from patients undergoing elective radical or simple nephrectomy. Digital images of each section from the distal arterial bifurcation to the proximal margin were obtained and analyzed after immunohistochemical staining with anti-tyrosine hydroxylase antibodies. A total of 3,075 nerve fibers were identified from 84 sections of peri-renal arterial tissue from 28 patients (mean age 62.5 ± 10.2 years, male 68%). Overall, 16% of nerve fibers were located at distances greater than 3 mm from the endoluminal surface of the renal artery. The median distance from the arterial lumen to the nerve fibers of the proximal, middle, and distal renal arterial segments was 1.51 mm, 1.48 mm, and 1.52 mm, respectively. The median diameter of the nerve fibers was 65 μm, and there was no significant difference between the segments. A substantial proportion of the sympathetic nerve fibers were located deeper in the peri-arterial soft tissue than in the lesion depth created by the conventional catheter-based renal sympathetic denervation system.
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Choe et al. (2019) conducted a cross-sectional in Elective radical or simple nephrectomy (n=28). Peri-renal sympathetic nerve distribution was evaluated on Distance of sympathetic nerve fibers from the endoluminal surface of the renal artery. In living human tissues, the median distance of peri-renal sympathetic nerve fibers from the renal artery lumen was 1.50 mm, with 16% of fibers located beyond 3 mm, deeper than conventional renal denervation lesion depths.
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