Key result
Radiofrequency catheter-based renal artery denervation in a porcine model induced circumscribed transmural injury, acute endothelial loss with thrombus formation, and delayed autonomic nerve degeneration.
Why the study?
Does radiofrequency catheter-based sympathetic denervation induce specific morphological changes in the renal arteries of a porcine model?
Population
7 pigs (renal arteries assigned to acute n=6, subacute n=6, control n=2)
Comparison
Radiofrequency catheter-based sympathetic… vs Untreated control (n=2 renal arteries)
Design
Preclinical
Follow-up
10 days
Authors
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Potential acute vascular risks in porcine models warrant clinical caution; leaves open human safety and durability of RDN.
Does radiofrequency catheter-based sympathetic denervation induce specific morphological changes in the renal arteries of a porcine model?
Radiofrequency renal denervation causes acute transmural injury and endothelial loss with thrombus formation, followed by rapid re-endothelialization and delayed nerve degeneration.
Steigerwald et al. (2012) studied Renal artery denervation (model for drug-resistant essential hypertension) (n=7). Radiofrequency catheter-based sympathetic denervation vs. Untreated control group was evaluated on Morphological changes within the vessel wall. Radiofrequency catheter-based renal artery denervation in a porcine model induced circumscribed transmural injury, acute endothelial loss with thrombus formation, and delayed autonomic nerve degeneration.
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