Why the study?
Do different modalities of chronic stress alter lipid metabolism in adult male rats?
Do different modalities of chronic stress alter lipid metabolism in adult male rats?
Different modalities of chronic stress produce distinct effects on lipid metabolism in rats, with paradoxical sleep deprivation uniquely increasing both HDL and LDL cholesterol.
Findings in rats should not alter clinical practice; leaves open whether stress modalities differentially affect human lipids.
Stress has been implicated in the pathogenesis of several diseases. In this study, we evaluated the effects of different chronic modalities of stress, namely paradoxical sleep deprivation (PSD), electrical footshock (FS), forced swim (SW), and restraint (R), on blood parameters associated with cardiovascular risk in adult male rats. FS and SW were applied twice per day for periods of one hour at 09:00 and 16:00h. Restrained animals were maintained in plastic cylinders for 22 h/day, whereas PSD was continuous. Rats were submitted to all stress modalities for four consecutive days. Our results demonstrated that PSD induced a significant increase in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol concentrations and led to a reduction in the levels of triglycerides and very low-density lipoprotein (VLDL) cholesterol. SW and R groups showed a decrease in total cholesterol and HDL cholesterol fractions, and FS increased LDL cholesterol concentrations. The PSD group displayed the highest concentrations of HDL and LDL compared to other groups (SW and R). These results suggest that each type of stress produces distinct effects on lipid metabolism.
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Andersen et al. (2009) studied this question.
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