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August 28, 2011Lipids in Health and DiseaseOpen Access

The model of rat lipid metabolism disorder induced by chronic stress accompanying high-fat-diet

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Why the study?

Does chronic stress combined with a high-fat diet induce a lipid metabolism disorder model in male Wistar rats?

Population

24 male Wistar rats

Comparison

Chronic stress combined with high-fat-diet vs Normal diet and high-fat-diet alone

Design

Preclinical, randomly divided into 3 groups

Follow-up

55 days

Authors

LMLin MantingLJLi JingSCShaodong Chen

Discussion

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Overview

Supports preclinical models of stress-diet synergy in dyslipidemia; leaves open human translation pending clinical validation.

Structured PICO

Does chronic stress combined with a high-fat diet induce a lipid metabolism disorder model in male Wistar rats?

P
Population
24 male Wistar rats
I
Intervention
Chronic stress combined with high-fat-diet (chronic stress daily for 21 days starting from the 35th day of a 55-day high-fat-diet)
C
Comparator
Normal diet (Group A) and high-fat-diet alone (Group B)
O
Outcome
Activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and levels of serum triglyceride (TG), Cholesterol (Ch), high-density lipoprotein-Cholesterol (HDL-C) and liver TGsurrogate

Chronic stress combined with a high-fat diet synergistically induces a lipid metabolism disorder in rats that mimics human clinical characteristics.

Cite This Study

Manting et al. (2011) studied this question.

synapsesocial.com/papers/6a7e9245ec6d7e203fcd9e66https://doi.org/10.1186/1476-511x-10-153
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