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November 14, 2018Lipids in Health and DiseaseOpen Access

Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model

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Why the study?

Does a high-fat high-cholesterol diet induce cardiac lipid dysregulation and heart damage in male Sprague-Dawley rats?

Population

Male Sprague-Dawley rats

Comparison

High-fat high-cholesterol diet for 2 or 4 weeks vs Normal chow diet

Design

Preclinical

Follow-up

Up to 4 weeks

Authors

QHQian HanSYSze C. YeungMIMsm Ip

Discussion

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Overview

HFHC diet disrupts cardiac lipids in rats; leaves open human relevance and requires clinical validation before practice implications.

Structured PICO

Does a high-fat high-cholesterol diet induce cardiac lipid dysregulation and heart damage in male Sprague-Dawley rats?

P
Population
Male Sprague-Dawley rats
I
Intervention
High-fat high-cholesterol (HFHC) diet for 2 or 4 weeks
C
Comparator
Normal chow diet
O
Outcome
Cardiac lipid parameters and cardiac damage (including lipid peroxidation, FABPs, interstitial fibrosis, and troponin I)surrogate

A high-fat high-cholesterol diet induces systemic and cardiac lipid dysregulation, oxidative stress, and subsequent cardiac damage in a rat model.

Cite This Study

Han et al. (2018) studied this question.

synapsesocial.com/papers/6a7cfa885ea1f309fbcd9099https://doi.org/10.1186/s12944-018-0905-3
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