Key result
Following 7-day heparin treatment, P-selectin and HIT antibodies increased in PAOD patients and were elevated in 9 patients who developed thrombotic complications during hospitalization.
Why the study?
Do P-selectin and HIT antibody levels change after 7-day heparin treatment in patients with venous or arterial diseases?
Cohort (n=78)
Do P-selectin and HIT antibody levels change after 7-day heparin treatment in patients with venous or arterial diseases?
Concomitant increase in P-selectin and HIT antibodies in PAOD patients receiving heparin may serve as a useful marker for forthcoming life-threatening thrombotic complications.
No takes yet. Share an insight, caveat, or question.
May flag thrombotic risk in heparin-treated PAOD; leaves open whether serial monitoring improves outcomes.
Papalambros et al. (2004) conducted a cohort in Arterial thromboembolism, deep vein thrombosis, and peripheral arterial occlusive disease (n=78). Heparin treatment vs. Baseline (day 1) and healthy controls was evaluated on P-selectin and HIT antibodies on day 7. Following 7-day heparin treatment, P-selectin and HIT antibodies increased in PAOD patients and were elevated in 9 patients who developed thrombotic complications during hospitalization.
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