Key result
The platelet collagen receptor GPIa T807 allele was significantly associated with an increased risk of stroke in patients ≤50 years of age (OR 3.02; 95% CI 1.20-7.61; P=0.023).
Why the study?
Is the GPIa T807/A873 allele an independent risk factor for the development of stroke in younger patients?
Case-Control (n=397)
Is the GPIa T807/A873 allele an independent risk factor for the development of stroke in younger patients?
Odds Ratio: 3.02 (95% CI 1.2–7.61)
p-value: p=0.023
The platelet collagen receptor GPIa-IIa T807 allele may be an independent genetic risk factor for stroke in patients aged 50 years or younger.
No takes yet. Share an insight, caveat, or question.
Should not yet change practice in young stroke patients; leaves open prospective validation of this genetic association.
Carlsson et al. (1999) conducted a case-control in Stroke (n=397). GPIa T807 allele vs. Absence of T807 allele was evaluated on Stroke in patients <=50 years of age (OR 3.02, 95% CI 1.20 to 7.61, p=0.023). The platelet collagen receptor GPIa T807 allele was significantly associated with an increased risk of stroke in patients ≤50 years of age (OR 3.02; 95% CI 1.20-7.61; P=0.023).
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