February 1, 2003AJP Heart and Circulatory Physiology
Basis for the cardiac-related rhythm in muscle sympathetic nerve activity of humans
Key result
Analysis of muscle sympathetic nerve activity revealed that in 54 of 98 cases, ≥15% of cardiac-related power remained after partialization with the ECG, supporting a nonlinear oscillator model.
Population
Humans (98 cases analyzed)
Authors
Discussion
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Implication
Refines models of sympathetic neural control; leaves open clinical relevance for autonomic assessment in cardiovascular disease.
Key Points
- The study aims to assess how cardiac-related rhythms in muscle sympathetic nerve activity are influenced by central oscillator dynamics and baroreceptor activity.
- Analyzed 98 cases of muscle sympathetic nerve activity using partial autospectral analysis to isolate cardiac-related power.
- Assessed the ECG-MSNA interval on a burst-by-burst basis to explore relationships between cardiac signals and nerve activity.
- Compared residual cardiac-related power frequencies to heart rate variability.
- > or =15% of cardiac-related power persisted post-ECG partialization in 54 cases.
- An inverse correlation was observed in four subjects between ECG-MSNA interval and burst amplitude.
- In 45% of cases, the ECG-MSNA interval and burst amplitude showed no correlation.
Structured PICO
P
Population
Humans (98 cases analyzed)
E
Exposure
Partial autospectral analysis to mathematically remove the portion of cardiac-related power in MSNA autospectra attributable to its linear relationship to the ECG
O
Outcome
Cardiac-related power in MSNA autospectra remaining after partialization with the ECG, and relationship between ECG-MSNA interval and cardiac-related burst amplitudesurrogate
The cardiac-related rhythm in muscle sympathetic nerve activity likely reflects forcing of a nonlinear oscillator rather than periodic inhibition of unstructured, random activity.
Cite This Study
Barman et al. (2003) studied this question. Partial autospectral analysis was evaluated on Cardiac-related power in MSNA autospectra. Analysis of muscle sympathetic nerve activity revealed that in 54 of 98 cases, ≥15% of cardiac-related power remained after partialization with the ECG, supporting a nonlinear oscillator model.