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January 1, 1991Japanese Circulation JournalOpen Access

11 patients with syncope showed a significantly lower heart rate response to isoproterenol than 17 patients without syncope, who had responses similar to normal subjects.

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Why the study?

Do heart rate responses to autonomic drugs correlate with syncope and electrophysiologic data in patients with sick sinus syndrome?

Population

28 patients with sick sinus syndrome (17 without syncope, 11 with syncope) and 8 normal subjects

Comparison

Intravenous administration of isoproterenol… vs Normal subjects and baseline measurements before…

Design

Cross-sectional

Authors

HOHidemi OgawaTITomoo InoueSMS Miwa

Discussion

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Overview

Blunted isoproterenol response may flag syncope risk in sick sinus syndrome; leaves open whether autonomic testing refines stratification.

Structured PICO

Do heart rate responses to autonomic drugs correlate with syncope and electrophysiologic data in patients with sick sinus syndrome?

P
Population
28 patients with sick sinus syndrome (17 without syncope, 11 with syncope) and 8 normal subjects
I
Intervention
Intravenous administration of isoproterenol, propranolol, atropine, and methoxamine, as well as pharmacologic autonomic blockade
C
Comparator
Normal subjects (n=8) and baseline measurements before drug administration
O
Outcome
Heart rate and automaticity recovery time (ART) before and after drug administrationsurrogate

Preserved sympathetic response to isoproterenol may compensate for impaired intrinsic automaticity and prevent syncope in patients with sick sinus syndrome.

Cite This Study

Ogawa et al. (1991) studied this question.

synapsesocial.com/papers/6a23c8be96b50e6ae79f0b6ehttps://doi.org/10.1253/jcj.55.15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Heart rate responses in patients with sinus node disease compared to controls: Physiological implications and diagnostic possibilities1980 · 17 citations
  2. 2Heart rate responses in patients with sinus node disease compared to controls: physiological implications and diagnostic possibilities1980 · 7 citations
  3. 3Altered Autonomic Mechanisms in the Sick Sinus Syndrome and Diurnal Variations in the Parameters of Sinus Node Function : Symposium on Sinus Node Function and Its Abnormality1980 · 5 citations
  4. 4Studies on the mechanism of sinus node dysfunction in the sick sinus syndrome.1978 · 174 citations
  5. 5Autonomous influence on sinus node and AY node function in the elderly without significant heart disease: assessment with electrophysiological and autonomic tests1980 · 33 citations