Key result
Averaging data from multiple blood samples significantly improved the reproducibility of plasma norepinephrine levels between sessions (r=0.63, P<0.03) compared to a single sample (r=0.42, P=NS).
Why the study?
Does multiple blood sampling improve the reproducibility of plasma norepinephrine measurements compared to single sampling in patients with essential hypertension?
Population
14 untreated mild-to-moderate essential hypertensive patients
Comparison
Multiple blood sampling for plasma… vs Single blood sample for plasma norepinephrine…
Design
Cohort
Follow-up
10-14 days
Authors
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Multiple sampling may enhance norepinephrine reproducibility in hypertension; leaves open whether this refines risk stratification or warrants routine adoption.
Observational (n=14)
Does multiple blood sampling improve the reproducibility of plasma norepinephrine measurements compared to single sampling in patients with essential hypertension?
Effect estimate: r=0.63
p-value: p=<0.03
Performing plasma norepinephrine assays on multiple blood samples substantially improves its reproducibility as an adrenergic marker in essential hypertension.
Grassı et al. (2008) conducted an observational in Essential hypertension (n=14). Multiple blood sampling for plasma norepinephrine assay vs. Single blood sample was evaluated on Reproducibility of plasma norepinephrine between sessions (r=0.63, p=<0.03). Averaging data from multiple blood samples significantly improved the reproducibility of plasma norepinephrine levels between sessions (r=0.63, P<0.03) compared to a single sample (r=0.42, P=NS).
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