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January 1, 1996Japanese Heart JournalOpen Access

Intracellular Calcium Modulators for Cardiac Muscle in Pathological Conditions.

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Key result

Agents that stabilize calcium release from the sarcoplasmic reticulum may be useful to correct abnormalities in calcium overload, though currently available agents lack cardiac specificity.

Population

Cardiac muscle in pathological conditions with calcium overload

Design

Review

Authors

NINobumasa IshideUniversity of Washington

Discussion

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Implication

May support calcium stabilizer investigation in overload states; leaves open cardiac-specific agent development for trials.

Structured PICO

P
Population
Cardiac muscle in pathological conditions with calcium overload
I
Intervention
Agents that stabilize calcium release from the sarcoplasmic reticulum (magnesium ion, ryanodine, caffeine, dantrolene, phenytoin, R56865, KT361, flunarizine)

Agents stabilizing sarcoplasmic reticulum calcium release offer a potential therapeutic strategy for cardiac calcium overload without compromising contractility.

Limitations

  • Currently available agents that could be expected to stabilize Ca release from cardiac SR are not specific for cardiac muscle and remain in the prototype stage.
  • Lack of clinically available methods to detect spontaneous Ca release from the sarcoplasmic reticulum.

Cite This Study

Nobumasa Ishide (1996) conducted a review in Calcium overload in cardiac muscle. Intracellular Calcium Modulators was evaluated. Agents that stabilize calcium release from the sarcoplasmic reticulum may be useful to correct abnormalities in calcium overload, though currently available agents lack cardiac specificity.

synapsesocial.com/papers/6a23ce8955bd20cf6fa63aechttps://doi.org/10.1536/ihj.37.1
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Also Consider

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  1. 1Inhibition of sodium and calcium overload pathology in the myocardium: a new cytoprotective principle1993 · 107 citations
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  3. 3Effects of high-K low-Na, diltiazem, caffeine and Ba on spontaneous fluctuating contractile activities in rat cardiac muscle.1984 · 2 citations
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  5. 5Effect of the Skeletal Muscle Relaxant Dantrolene Sodium on the Isolated, Perfused Heart1979 · 12 citations