Why the study?
Does atenolol alter sinus node and ventricular repolarization parameters in healthy volunteers?
Population
16 healthy volunteers (10 males, mean age: 40 +/- 6.7 years)
Comparison
Atenolol 100 mg oral for 7 days vs Placebo for 7 days (crossover design)
Design
RCT, Randomized to placebo or atenolol, crossed over after 7 days
Follow-up
7 days per treatment arm
Authors
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Atenolol reduces diurnal QT rate-dependence in healthy volunteers; extends beta-blocker effects on repolarization beyond heart rate slowing.
Does atenolol alter sinus node and ventricular repolarization parameters in healthy volunteers?
In healthy subjects, chronic beta-blockade with atenolol alters diurnal QT rate-dependence, which correlates with pretreatment QT/RR relation rather than heart rate changes.
Extramiana et al. (2002) studied this question.
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