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May 1, 1983AJP Heart and Circulatory Physiology

Both adenosine and acetylcholine hyperpolarize the resting membrane to the potassium equilibrium potential and cause a marked abbreviation of the action potential by increasing steady-state potassium currents.

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Population

Calcium-tolerant single myocytes isolated from guinea pig atria

Design

Preclinical

Authors

LBL BelardinelliGIG Isenberg

Discussion

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Overview

Supports mechanistic insights into atrial electrophysiology; leaves open translation to human arrhythmias.

Structured PICO

P
Population
Calcium-tolerant single myocytes isolated from guinea pig atria
I
Intervention
Adenosine and acetylcholine
O
Outcome
Intracellular action potentials and membrane currentssurrogate

Adenosine and acetylcholine hyperpolarize atrial myocytes and shorten the action potential by increasing potassium conductance via a common mechanism.

Cite This Study

Belardinelli et al. (1983) studied this question.

synapsesocial.com/papers/6a23d4eba98279854dd370efhttps://doi.org/10.1152/ajpheart.1983.244.5.h734
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