Key result
An increase in ejection fraction with low-dose dobutamine infusion strongly predicted post-operative left ventricular functional recovery (adjusted OR 1.81; 95% CI 1.30-2.52; P=0.0005).
Why the study?
Does pre-operative assessment with PET or dobutamine echocardiography predict global left ventricular functional recovery after CABG in patients with severe left ventricular dysfunction?
Cohort (n=66)
Does pre-operative assessment with PET or dobutamine echocardiography predict global left ventricular functional recovery after CABG in patients with severe left ventricular dysfunction?
Odds Ratio: 1.81 (95% CI 1.3–2.52)
p-value: p=0.0005
An increase in ejection fraction during low-dose dobutamine infusion is the strongest predictor of global left ventricular functional recovery after CABG in patients with severe LV dysfunction.
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May guide preoperative viability assessment before CABG in severe LV dysfunction; leaves open need for randomized outcome trials.
Agnès Pasquet (2000) conducted a cohort in Severe left ventricular dysfunction (n=66). Increase in ejection fraction with low-dose dobutamine was evaluated on Post-operative left ventricular functional recovery (defined by a 5% increment of ejection fraction) (adjusted OR 1.81, 95% CI 1.30-2.52, p=0.0005). An increase in ejection fraction with low-dose dobutamine infusion strongly predicted post-operative left ventricular functional recovery (adjusted OR 1.81; 95% CI 1.30-2.52; P=0.0005).
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