Key result
Decreased expression and activity of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells contribute to increased pulmonary vasoconstriction in pulmonary arterial hypertension.
Population
Pulmonary arterial smooth muscle cells in the context of pulmonary vascular diseases such as pulmonary…
Design
Review
Authors
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Kv channel restoration may warrant preclinical testing in PAH; leaves open clinical efficacy and safety of targeted therapies.
Voltage-dependent K+ channels in pulmonary arterial smooth muscle cells are crucial for maintaining resting membrane potential and vascular tone, and their dysfunction contributes to pulmonary arterial hypertension, highlighting them as potential therapeutic targets.
Park et al. (2010) conducted a review in Pulmonary arterial hypertension. Voltage-dependent K+ (Kv) channels was evaluated. Decreased expression and activity of voltage-dependent K+ channels in pulmonary arterial smooth muscle cells contribute to increased pulmonary vasoconstriction in pulmonary arterial hypertension.
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