Population
Rat fibroblasts (SR-3Y1 cells and 3Y1 cells)
Comparison
src gene transfection / calvasculin expression vs Untransfected 3Y1 cells
Design
Preclinical
Authors
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Calvasculin may mediate cytoskeletal disruption in src-transformed fibroblasts; hypothesis-generating for oncogenesis with no clinical implications yet.
The study suggests that the disorganization of microfilaments in src-transformed SR-3Y1 cells is due to the Ca(2+)-dependent cross-linking activity of elevated calvasculin.
Watanabe et al. (1993) studied this question.
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