Diffusion limitation in normal humans during exercise at sea level and simulated altitude

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Why the study?

Does exercise at simulated altitude induce alveolar-capillary diffusion disequilibrium in normal men?

Population

9 normal unacclimatized men

Comparison

Bicycle exercise at sea level and three… vs Rest at corresponding altitudes

Authors

Discussion

May contribute to exertional hypoxemia at altitude; leaves open its magnitude after acclimatization or in cardiopulmonary disease.

Does exercise at simulated altitude induce alveolar-capillary diffusion disequilibrium in normal men?

Population

9 normal unacclimatized men

Intervention

Bicycle exercise at sea level and three simulated altitudes (5,000, 10,000, and 15,000 ft)

Comparator

Rest at corresponding altitudes

Outcome

Arterial PO2 and alveolar-arterial PO2 differencessurrogate

Exercise at high altitudes (≥10,000 ft) induces significant alveolar-capillary diffusion disequilibrium for oxygen in normal unacclimatized men.

Torre-Bueno et al. (1985) studied this question.

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